The United States Medical Licensing Examination (USMLE) is a three-step examination program for medical licensure in the United States sponsored by the Federation of State Medical Boards (FSMB) and the National Board of Medical Examiners (NBME).Physicians with a Doctor of Medicine (MD) degree are required to pass the USMLE for medical licensure. However, those with a Doctor of Osteopathic Medicine degree (DO) are required to take the COMLEX-USA (COMLEX) exams.States may enact additional testing and/or licensing requirementsThe United States Medical Licensing Examination (USMLE) is a multistep assessment required for medical licensure in the United States by all graduates of M.D.-granting American medical schools as well as all graduates of international medical schools.